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Publicity to your glucuronide metabolite is 35 to forty situations increased than exposure to the parent drug. In vitro facts advise that hydromorphone in clinically related concentrations has nominal potential to inhibit the activity of human hepatic CYP450 enzymes which include CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.Tell your health practitioner i